Pharmacological Effects of Peganum harmala Seeds Extract on Isolated Rat Uterus
Authors
Abstract:
The effects of hydroalcoholic extract of Peganum harmala seeds (EPS) on spontaneous rhythmic contractions of isolated rat uterine was investigated in this study. EPS was tested on the isolated uterus and endometrium free (i.e. stripped myometrium) preparations. EPS was found to exhibit significant spontaneous contractions of the uterus and stripped myometrium relative to the solvent control. After recording the pattern of uterus tissue spontaneous motility, in order to determine mechanism of EPS pharmacological effects, atropine, indomethacin, or prazocin was added into the organ baths. Pretreatment with atropine (70 nM) in both the whole uterus and in the stripped myometrium preparations had no effects on the response to cumulative dosage of EPS. Calcium-free solution decreased the uterus contractions. In calcium dose-response curves, EPS in some concentrations produced uterotonic effect in calcium-free solution in the presence of KCl. This finding showed that EPS may increase calcium influx through voltage-dependant calcium channels.
similar resources
pharmacological effects of peganum harmala seeds extract on isolated rat uterus
the effects of hydroalcoholic extract of peganum harmala seeds (eps) on spontaneous rhythmic contractions of isolated rat uterine was investigated in this study. eps was tested on the isolated uterus and endometrium free (i.e. stripped myometrium) preparations. eps was found to exhibit significant spontaneous contractions of the uterus and stripped myometrium relative to the solvent control. af...
full textVasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seeds in isolated rat aorta.
The present work describes the mechanisms involved in the vasorelaxant effect of harmine and harmaline. These alkaloids induce in a dose-dependent manner the relaxation in the aorta precontracted with noradrenaline or KCl. However, the removal of endothelium or pre-treatment of intact aortic ring with L-NAME (inhibitor of NOSe synthetase) or with indomethacin (non-specific inhibitor of cyclo-ox...
full textCytotoxicity of alkaloids isolated from Peganum harmala seeds.
ETHNOPHARMACOLOGICAL RELEVANCE Peganum harmala is used in traditional medicine to treat a number of diseases including cancer. Our preliminary studies show that the alkaloidal extract of PH seed is cytotoxic to several tumor cell lines in vitro and has antitumor effect in a tumor model in vivo. The present investigation was aimed at extending our previous studies in identifying the components i...
full textIn vitro and in vivo effects of Peganum harmala L. seeds extract against influenza A virus
Objective Influenza A virus infections are still a major health problem and the choices available for the control and treatment of the disease are limited. This research evaluated in vitro and in vivo antiviral effects of Peganum harmala L. seeds (PHS) extract against influenza A virus. Materials and Methods In this research, in vitro anti-influenza A virus activity of the extract was assesse...
full textAntifungal activity of Peganum harmala seeds extract in vitro
Peganum harmala (Zygophyllaceae) is an intriguing herb with a long history of medicinal use. Antifungal activity of P. harmala seed extract against certain fungal species was investigated in vitro. Antifungal activity of the extract of P. harmala seeds was investigated against several fungal species using in vitro agar dilution technique. The fungal species included: Microsporum canis, Microspo...
full textAntifungal activity of Peganum harmala seeds extract in vitro
Peganum harmala (Zygophyllaceae) is an intriguing herb with a long history of medicinal use. Antifungal activity of P. harmala seed extract against certain fungal species was investigated in vitro. Antifungal activity of the extract of P. harmala seeds was investigated against several fungal species using in vitro agar dilution technique. The fungal species included: Microsporum canis, Microspo...
full textMy Resources
Journal title
volume 2 issue 2
pages 81- 86
publication date 2006-04-01
By following a journal you will be notified via email when a new issue of this journal is published.
Keywords
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023